Philadelphia Eagles are managing a lengthy injury report ahead of their crucial Week 17 road matchup against the Buffalo Bills. The Eagles, sitting at 10-5, will face the 11-4 Bills at Highmark Stadium on Sunday, December 28, 2025, with kickoff scheduled for 4:25 p.m. ET.
Philadelphia currently has 11 players listed on its injury report, though the outlook is mixed, with several key contributors trending toward availability.
Eagles players ruled out vs Bills
The Eagles will be without two important starters for Sunday’s contest.
Lane Johnson (OT) has been ruled out due to a foot injury after failing to participate in practice. Johnson has appeared in four games during the 2025 season, and his absence impacts Philadelphia’s offensive line depth.
Nakobe Dean (LB) is also out after missing practice with a hamstring injury. Dean has been productive when healthy this season, recording 4.0 sacks, 7.0 tackles for loss, and 55 total tackles on the defensive side of the ball.
Questionable Philadelphia Eagles to monitor
Cameron Latu (TE) is the lone player listed as questionable. He is dealing with a stinger but practiced fully during the week. Latu has played in nine games this season, and his status will be finalized closer to kickoff.
Jalen Carter, A.J. Brown Among Players Expected to Play
There is encouraging news for Philadelphia, particularly on defense.
Jalen Carter (DT), who was listed with shoulder issues, practiced fully and is expected to play. Carter has posted 2.0 sacks, 4.0 tackles for loss, and 32 tackles in the 2025 season.
Philadelphia Eagles also saw full participation from several offensive and defensive contributors, including A.J. Brown, DeVonta Smith, Landon Dickerson, Fred Johnson, Cameron Williams, Jihaad Campbell, and Zack Baun. Brown continues to lead the receiving corps with 935 yards and seven touchdowns, while Smith has totaled 931 receiving yards this season.
Despite the number of names on the report, Philadelphia appears well-positioned health-wise heading into a marquee late-season matchup. With most starters expected to suit up, Philadelphia Eagles will look to remain competitive against one of the AFC’s top teams.