San Francisco 49ers have released their latest injury report ahead of their Week 16 showdown against the Indianapolis Colts, shedding light on several roster absences that could shape Monday night’s primetime clash at Lucas Oil Stadium.
With kickoff scheduled for 8:15 p.m. ET, the 49ers will need to adjust key rotations as they prepare to face an 8-6 Colts side on the road.
San Francisco enters the matchup at 10-4, firmly in the playoff hunt, but injuries across multiple position groups have added a layer of uncertainty heading into the contest.
Confirmed absences for Week 16
The most notable takeaway from the injury report is the list of players officially ruled out. Quarterback Kurtis Rourke will miss the game due to a knee injury despite logging full participation in practice.
His absence affects the team’s depth at the position, forcing San Francisco 49ers to rely on their remaining options behind center.
Wide receiver Ricky Pearsall has also been ruled out after failing to practice due to a knee issue. Pearsall has played a meaningful role in the passing game this season, recording 31 receptions for 443 yards, and his unavailability removes a reliable target from the offensive rotation.
Defensively, cornerback Renardo Green will sit out the Colts matchup after being limited in practice while dealing with a neck injury.
Green’s absence impacts the secondary, where he has contributed consistently with 52 tackles and nine passes defended this season.
Linebacker Nickolas Martin rounds out the list of players ruled out. Martin did not participate in practice due to a concussion, leaving San Francisco short-handed at linebacker for a physically demanding matchup against Indianapolis.
Question marks remain on the defensive line
While the list of confirmed absences is clear, the 49ers still have one key defensive decision to monitor. Defensive lineman Yetur Gross-Matos is listed as questionable after missing practice with a hamstring injury.
His availability could play a role in how San Francisco 49ers approaches its pass rush and defensive rotations against a Colts offense that has shown balance throughout the season.
Positive signs elsewhere on the roster
Despite the list of players set to miss the game, there is encouraging news for San Francisco. Several starters and rotational players, including Christian McCaffrey, Trent Williams, and multiple defensive contributors, logged full participation in practice.
McCaffrey’s inclusion on the report was related to rest, and he remains on track to feature prominently after another productive season on the ground and through the air.
Linebackers Tatum Bethune and Dee Winters, along with several offensive and defensive linemen, are also expected to be available, helping stabilize depth across the roster.
San Francisco 49ers will head into Monday night knowing exactly which players they must replace, particularly at wide receiver, cornerback, and linebacker.