San Francisco 49ers have released their final injury report ahead of their Week 16 “Monday Night Football” showdown against the Indianapolis Colts. With primetime stakes and playoff positioning in focus, the report offers clarity on who will suit up and who will miss out as Kyle Shanahan’s side prepares for another crucial road test.
Ricky Pearsall officially ruled out
Wide receiver Ricky Pearsall has been ruled out for the Colts matchup after sustaining a knee and ankle injury in last week’s game against the Tennessee Titans. Pearsall was close to returning but ultimately did not clear the final hurdle before Monday night.
“He was close,” Shanahan said after the team’s final practice of the week. “But not close enough.”
Pearsall’s absence removes a developing option from the 49ers’ receiving rotation, forcing San Francisco to lean more heavily on its established targets in the passing game.
Nick Martin placed on injured reserve
In another notable move, San Francisco 49ers placed linebacker Nick Martin on injured reserve. The decision sidelines Martin for the immediate future and further tests San Francisco’s depth at linebacker as the season reaches its most demanding stretch.
While the team did not specify a return timeline, the move confirms Martin will not be available against Indianapolis and signals a longer recovery process.
Yetur Gross-Matos questionable after missed practice
Defensive lineman Yetur Gross-Matos remains one of the key names to monitor. After being limited throughout the week, Gross-Matos did not participate in the team’s final practice and is officially listed as questionable with a hamstring injury.
His availability could have a significant impact on the 49ers’ defensive front, particularly against a Colts offense that relies on balance and physicality. A game-day decision is expected, with final status to be confirmed 90 minutes before kickoff.
Positive updates for Bethune and Okuayinonu
The injury report did include encouraging news. Linebacker Tatum Bethune has been cleared and is expected to play, while defensive lineman Sam Okuayinonu impressed during the week.
Shanahan confirmed Bethune is “good to go” and added that Okuayinonu “had a good week,” reinforcing optimism around their readiness for Monday night.
Full Week 16 game status report
San Francisco 49ers’ final injury designations for Week 16 are as follows:
Renardo Green (CB, neck) – OUT
Yetur Gross-Matos (DL, hamstring) – Questionable
Ricky Pearsall (WR, knee/ankle) – OUT
Kurtis Rourke (QB, knee) – OUT
San Francisco will continue to monitor all listed players, with final decisions on questionable designations announced closer to kickoff in Indianapolis.
Final outlook ahead of primetime
While San Francisco 49ers will be without a few contributors, the overall injury picture remains manageable heading into Monday night. How effectively San Francisco compensates for Pearsall’s absence and whether Gross-Matos can play may prove decisive as the team looks to deliver under the bright lights against the Colts.