San Francisco 49ers enter their regular-season finale with several key health questions as they prepare to host the Seattle Seahawks at Levi’s Stadium on Saturday, January 3.
With playoff positioning on the line and two NFC heavyweights set to collide, San Francisco’s latest injury report provides crucial insight into who may be available under the lights.
49ers currently have nine players listed, including several starters on both sides of the ball. While some designations raise concern, others offer optimism heading into kickoff.
Christian McCaffrey trending toward availability
All eyes remain on Christian McCaffrey, whose status carries major implications for San Francisco’s offensive game plan.
The star running back is dealing with a back issue but logged full participation in practice, a strong indicator that he is on track to play.
McCaffrey has once again been the engine of San Francisco 49ers’ offense in 2025, contributing heavily as both a runner and receiver.
His ability to line up across formations adds a layer of unpredictability that Seattle’s defense must account for if he is cleared.
Fullback Kyle Juszczyk is in a similar position, practicing fully despite a hip issue. His availability would further stabilize 49ers’ run-heavy approach.
Offensive concerns center on Trent Williams and George Kittle
Left tackle Trent Williams remains questionable after missing practice with a hamstring injury. Having appeared in just five games this season, Williams’ availability is critical for protecting the quarterback against Seattle’s aggressive pass rush.
Tight end George Kittle is also listed as questionable after limited participation due to an ankle issue. Kittle has been one of San Francisco’s most productive red-zone weapons in 2025, and his status will be closely monitored as the team finalizes its offensive personnel.
Wide receiver Ricky Pearsall rounds out the offensive question marks. Limited in practice with a knee injury, Pearsall has been a steady contributor in the passing game and would provide valuable depth if active.
Defensive unit managing multiple questionable designations
On defense, San Francisco 49ers are navigating uncertainty across multiple position groups. Defensive lineman Keion White was limited with a groin injury, while Yetur Gross-Matos did not participate due to a knee issue, placing his availability in doubt.
In the secondary, Upton Stout appears to be trending positively after full participation while in concussion protocol. Renardo Green also practiced fully despite a neck concern, positioning both defensive backs as likely options if no late setbacks occur.
San Francisco’s injury report reflects calculated caution rather than widespread alarm.