NFC West delivers one final heavyweight bout to close the regular season as the San Francisco 49ers host the Seattle Seahawks in a prime-time showdown on Saturday night. With playoff seeding, a first-round bye, and home-field advantage all hanging in the balance, this matchup stands as one of the most consequential games of the 2025 NFL season.
Both teams have already secured postseason berths, but the stakes could not be higher at Levi’s Stadium.
NFC West supremacy and the no. 1 seed at stake
Seattle enters Week 18 as the NFC West leader and current No. 1 seed in the conference with a 13-3 record. San Francisco trails closely at 12-4, setting up a winner-take-all scenario at the top of the NFC standings.
If the 49ers win, they would finish tied with Seattle at 13-4 and claim the conference’s top seed by virtue of sweeping the season series.
That outcome would secure a first-round bye and guarantee San Francisco home-field advantage throughout the NFC playoffs—a particularly meaningful edge with Super Bowl 60 scheduled to be played at Levi’s Stadium.
A Seahawks victory, however, locks Seattle into the No. 1 seed, granting them a bye and home-field advantage through the conference playoffs.
In that scenario, San Francisco would fall to the No. 5 seed at best and could slide to No. 6 depending on the outcome of the Rams-Cardinals matchup.
Prime-time setting adds to the drama
Saturday’s contest marks another prime-time chapter in one of the league’s most intense rivalries. The NFC West has been widely regarded as the NFL’s strongest division this season, and this game serves as a fitting finale.
San Francisco will also debut new jerseys for the occasion, adding another layer of intrigue to a night already loaded with significance.
Where to Watch 49ers vs Seahawks Live
TV Channels: ABC, ESPN
Start Time: 8:00 p.m. ET
The matchup will be broadcast nationally, with Joe Buck handling play-by-play duties and Troy Aikman providing analysis.
Live Streaming Options:
ESPN+
fuboTV
NFL+
49ers vs Seahawks Prediction
With everything on the line and San Francisco playing at home, expect a tightly contested battle that comes down to execution in key moments. The stakes favor urgency over caution, setting the stage for a high-intensity finish.
Prediction: 49ers 27, Seahawks 24