The San Francisco 49ers will visit the Indianapolis Colts on Monday Night Football on December 22, 2025, at Lucas Oil Stadium in Indianapolis. Both sides stand 3rd in the NFC and AFC standings, respectively. The 49ers are 10-4 ahead of entering this fixture, while the Colts are 8-6. They have won four straight games by 10-plus points. On the other hand, the Colts have lost four consecutive games.
49ers vs Colts Monday Night Football final injury report
For the Colts, Philip Rivers will be in action again as the 44-year-old quarterback returned to the field last week following a five-year hiatus. For the 49ers, Ricky Pearsall will be a notable absence who has been ruled out following a knee ans ankle injury. Ahead of the game, the teams released their final injury report, and here is a look at who is in and who is out.
49ers injury report
Along with Ricky Pearsall, CB Renardo will be out following a neck injury. WR Kurtis has also been sidelined due to a knee injury, just like Pearsall. Meanwhile, DE Yetur Gross-Matos, who is recovering from a hamstring injury, is questionable for the encounter.
Out
CB Renardo Green (neck)
WR Ricky Pearsall (knee, ankle)
QB Kurtis Rourke (knee)
Ouestionable
DE Yetur Gross-Matos (hamstring)
Colts injury report
CB Ahmad Gardner is out due to a calf issue for the Colts. WR Anthony Gould has been listed out following a foot injury, while QB Anthony Richardson is out following an eye injury. Safety Daniel Scott will also not play due to a knee injury. DT DeForest (neck) and Offensive Tackle Bernhard Raimann (elbow) are listed as questionable.
Out
CB Ahmad Gardner (calf)
WR Anthony Gould (foot)
QB Anthony Richardson (eye)
S Daniel Scott (knee)
Questionable
DT DeForest Buckner (neck)
T Bernhard Raimann (elbow)